Sugi Predict

Sugi Predict / Compounds / SCHEMBL4756596

SCHEMBL4756596

SCHEMBL4756596

O=C(Nc1ncc(S(=O)(=O)c2ccccc2)s1)c1cccc(F)c1O

nearest known ligand 0.66

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CRHBP P24387 2/20 0.66
▸ CRHR2 Q13324 2/20 0.66
▸ MEN1 O00255 4/20 0.56
▸ KMT2A Q03164 4/20 0.56
▸ MAPT P10636 4/20 0.56
▸ GRM4 Q14833 3/20 0.52
▸ SMN1; SMN2 Q16637 3/20 0.46
▸ LOXL2 Q9Y4K0 2/20 0.43
▸ RAB9A P51151 3/20 0.43
▸ NPC1 O15118 2/20 0.43
▸ STAT3 P40763 1/20 0.43
▸ ALDH1A1 P00352 3/20 0.42
▸ STIM1 Q13586 1/20 0.42
▸ ORAI1 Q96D31 1/20 0.42
▸ POLB P06746 1/20 0.42
▸ CASP3 P42574 1/20 0.42
▸ SENP7 Q9BQF6 1/20 0.42
▸ LMNA P02545 1/20 0.41
▸ RXFP1 Q9HBX9 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4757159 0.74 MEN1 (0.57) CRHBPCRHR2MEN1KMT2AMAPT
SCHEMBL4755798 0.72 STAT3 (0.63) CRHBPCRHR2MEN1KMT2AMAPT
SCHEMBL4756932 0.72 MEN1 (0.59) CRHBPCRHR2MEN1KMT2AMAPT
SCHEMBL4756542 0.71 STAT3 (0.47) CRHBPCRHR2MEN1KMT2AMAPT
SCHEMBL4755842 0.70 STAT3 (0.47) CRHBPCRHR2MEN1KMT2AMAPT
SCHEMBL19224557 0.70 LOXL2 (0.59) LOXL2ALDH1A1POLB
SCHEMBL10114538 0.70 KMT2A (0.55) CRHBPCRHR2MEN1KMT2AMAPT
SCHEMBL31426452 0.70 STAT3 (0.58) CRHBPCRHR2MEN1KMT2AMAPT
SCHEMBL28846379 0.70 HPGD (0.52) CRHBPCRHR2MEN1KMT2AMAPT
SCHEMBL704075 0.70 STAT3 (0.58) CRHBPCRHR2MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8895752-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES L.C. (US) 2014-11-25 — — US disclosed
US-8895752-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES L.C. (US) 2014-11-25 — — US disclosed
US-20120122939-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES, L.C. 2012-05-17 — — US disclosed
US-20120122939-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES, L.C. 2012-05-17 — — US disclosed
US-8124632-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES, L.C. (US) 2012-02-28 — — US disclosed
US-8124632-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES, L.C. (US) 2012-02-28 — — US disclosed
WO-2009035788-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES L.C. (US) 2009-03-19 — — WO disclosed
US-20090036467-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES L.C. 2009-02-05 — — US disclosed
US-20090036467-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES L.C. 2009-02-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122939-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS HAVCR2, EIF2AK2, AADAC CRHBP 3994/4885CRHR2 4813/4885MEN1 4564/4885
US-20090036467-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS HAVCR2, EIF2AK2, AADAC CRHBP 3994/4885CRHR2 4813/4885MEN1 4564/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.