SCHEMBL4756635

SCHEMBL4756635

NC(=O)[C@H]1CN(c2cc(F)c(N3CC(F)(F)C3)c(F)c2)C(=O)O1

nearest known ligand 0.71

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.71
CALML3 P27482 7/20 0.35
F10 P00742 1/20 0.35
MAOB P27338 6/20 0.34
LMNA P02545 1/20 0.34
PTGS1 P23219 1/20 0.34
SDHA P31040 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4790680 0.90 MAOA (0.58) MAOACALML3F10MAOBLMNA
SCHEMBL4756911 0.90 MAOA (0.58) MAOACALML3F10MAOBLMNA
SCHEMBL4758477 0.86 MAOA (0.65) MAOACALML3F10MAOBLMNA
SCHEMBL4704302 0.86 MAOA (0.65) MAOACALML3F10MAOBLMNA
SCHEMBL4758473 0.85 MAOA (0.64) MAOACALML3F10MAOBLMNA
SCHEMBL4705310 0.85 MAOA (0.74) MAOACALML3F10MAOBLMNA
SCHEMBL3038452 0.85 MAOA (0.74) MAOACALML3F10MAOBLMNA
SCHEMBL6689288 0.85 MAOA (0.74) MAOACALML3F10MAOBLMNA
SCHEMBL4703986 0.85 MAOA (0.57) MAOACALML3F10MAOBLMNA
SCHEMBL6209205 0.84 MAOA (0.72) MAOACALML3F10MAOBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1902048-A1 OXAZOLIDINONE CARBOXAMIDES CONTAINING AZETIDINE AND CYCLOBUTANE AS ANTIBACTERIAL AGENTS Pharmacia & Upjohn Company LLC (US) 2008-03-26 EP disclosed
WO-2007004037-A1 OXAZOLIDINONE CARBOXAMIDES CONTAINING AZETIDINE AND CYCLOBUTANE AS ANTIBACTERIAL AGENTS PHARMACIA & UPJOHN COMPANY LLC (US) 2007-01-11 WO disclosed