Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 8/20 | 0.51 |
| ▸ | RAF1 | P04049 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 7/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
| ▸ | KIF15 | Q9NS87 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652100 | 0.90 | TLK2 (0.41) | TLK2RAF1JAK3NTRK1PDPK1 | |
| SCHEMBL3652102 | 0.90 | TLK2 (0.41) | TLK2RAF1JAK3NTRK1PDPK1 | |
| SCHEMBL3587084 | 0.80 | PDPK1 (0.58) | TLK2RAF1JAK3NTRK1PDPK1 | |
| SCHEMBL3587087 | 0.80 | TLK2 (0.53) | TLK2RAF1JAK3NTRK1PDPK1 | |
| SCHEMBL3571577 | 0.78 | TLK2 (0.53) | TLK2RAF1JAK3NTRK1PDPK1 | |
| SCHEMBL3571572 | 0.78 | PDPK1 (0.55) | TLK2RAF1JAK3NTRK1PDPK1 | |
| SCHEMBL3578104 | 0.75 | JAK3 (0.55) | TLK2RAF1JAK3PDPK1 | |
| SCHEMBL3578101 | 0.75 | JAK3 (0.55) | TLK2RAF1JAK3PDPK1 | |
| SCHEMBL3576565 | 0.73 | JAK3 (0.60) | TLK2RAF1JAK3PDPK1 | |
| SCHEMBL3576563 | 0.73 | JAK3 (0.60) | TLK2RAF1JAK3PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902025-A1 | KINASE INHIBITORS | Allergan, Inc. (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | disclosed |