Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.41 |
| ▸ | TGM2 | P21980 | 5/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.37 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652100 | 1.00 | TLK2 (0.41) | TLK2TGM2RAF1PIM1ALDH1A1 | |
| SCHEMBL4756765 | 0.90 | TLK2 (0.51) | TLK2RAF1JAK3NTRK1CCNB2 | |
| SCHEMBL3580637 | 0.81 | PDPK1 (0.47) | TLK2TGM2RAF1PIM1ALDH1A1 | |
| SCHEMBL3572836 | 0.80 | AURKB (0.38) | TLK2TGM2RAF1JAK3NTRK1 | |
| SCHEMBL3580640 | 0.80 | PIM1 (0.51) | TLK2TGM2RAF1PIM1ALDH1A1 | |
| SCHEMBL3580971 | 0.79 | PIM1 (0.46) | TLK2TGM2RAF1PIM1ALDH1A1 | |
| SCHEMBL3580973 | 0.78 | PIM1 (0.54) | TLK2TGM2RAF1PIM1ALDH1A1 | |
| SCHEMBL2573839 | 0.76 | PIM1 (0.57) | TLK2TGM2PIM1ALDH1A1MAPT | |
| SCHEMBL2573841 | 0.76 | PIM1 (0.57) | TLK2TGM2PIM1ALDH1A1MAPT | |
| SCHEMBL3811917 | 0.76 | MAOA (0.42) | TGM2PIM1ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010075197-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2010-07-01 | — | — | WO | disclosed |