Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9201256 | 0.77 | MAPT (0.49) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL10921523 | 0.76 | MAPT (0.55) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL11073588 | 0.74 | MAPT (0.54) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL5267660 | 0.73 | MAPT (0.62) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL9347725 | 0.73 | CYP1A2 (0.56) | CYP1A2CYP2C19MAPK14 | |
| SCHEMBL11283662 | 0.70 | NOX1 (0.56) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL10989656 | 0.70 | NOX1 (0.59) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL5365533 | 0.69 | GAA (0.51) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL10799922 | 0.69 | MAPT (0.54) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL11072287 | 0.69 | NOX1 (0.52) | MAPTGAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008110921-A | ADVANCED GLYCATION END PRODUCT FORMATION INHIBITOR COMPRISING PYRAZINE DERIVATIVE AS ACTIVE INGREDIENT | KOWA CO | 2008-05-15 | — | — | JP | disclosed |