Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | PDE5A | O76074 | 1/20 | 0.59 |
| ▸ | GRM5 | P41594 | 2/20 | 0.49 |
| ▸ | GCK | P35557 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757358 | 0.80 | MAPT (0.50) | MAPK1HTTPDE5AGRM5GCK | |
| SCHEMBL4757054 | 0.76 | PDE5A (0.47) | MAPK1HTTPDE5AGCKLMNA | |
| SCHEMBL4756969 | 0.76 | FDPS (0.46) | HTTLMNATSHRCYP3A4MAPT | |
| SCHEMBL20662872 | 0.76 | MAPT (0.64) | MAPK1HTTPDE5ALMNATSHR | |
| SCHEMBL4757309 | 0.75 | NPC1 (0.47) | MAPK1PDE5AGCKCYP3A4MAPT | |
| SCHEMBL9570944 | 0.73 | SMN1; SMN2 (0.69) | HTTLMNAKMT2AALDH1A1 | |
| SCHEMBL10131601 | 0.71 | GRM5 (0.47) | MAPK1HTTPDE5AGRM5GCK | |
| SCHEMBL10114414 | 0.71 | GRM5 (0.68) | HTTGRM5GCKCYP3A4MAPT | |
| SCHEMBL11222597 | 0.71 | SMN1; SMN2 (0.49) | MAPK1PDE5ALMNATSHRMEN1 | |
| SCHEMBL10114477 | 0.70 | GRM5 (0.46) | MAPK1HTTPDE5AGRM5GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895752-B2 | Alkylsulfonyl-substituted thiazolide compounds | ROMARK LABORATORIES L.C. (US) | 2014-11-25 | — | — | US | disclosed |
| US-20120122939-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | ROMARK LABORATORIES, L.C. | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122939-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | HAVCR2, EIF2AK2, AADAC | MAPK1 3595/4885HTT 1888/4885PDE5A 4694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.