Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699779 | 1.00 | ALDH1A1 (0.41) | ALDH1A1GAAAURKARPS6KB1ANPEP | |
| SCHEMBL177215 | 1.00 | ALDH1A1 (0.41) | ALDH1A1GAAAURKARPS6KB1ANPEP | |
| SCHEMBL10002494 | 1.00 | ALDH1A1 (0.41) | ALDH1A1GAAAURKARPS6KB1ANPEP | |
| SCHEMBL177088 | 1.00 | ALDH1A1 (0.41) | ALDH1A1GAAAURKARPS6KB1ANPEP | |
| SCHEMBL3092977 | 1.00 | ALDH1A1 (0.41) | ALDH1A1GAAAURKARPS6KB1ANPEP | |
| SCHEMBL3327022 | 0.83 | ALDH1A1 (0.41) | ALDH1A1GAANAMPTMEN1KMT2A | |
| SCHEMBL8410178 | 0.83 | ALDH1A1 (0.41) | ALDH1A1GAANAMPTMEN1KMT2A | |
| SCHEMBL8045772 | 0.83 | ALDH1A1 (0.41) | ALDH1A1GAANAMPTMEN1KMT2A | |
| SCHEMBL4283036 | 0.81 | ALDH1A1 (0.41) | ALDH1A1GAAANPEPKDM1AATM | |
| SCHEMBL562899 | 0.81 | KDM1A (0.42) | ALDH1A1GAAANPEPKDM1AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |