Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 13/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 7/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 4/20 | 0.39 |
| ▸ | PLA2G2E | Q9NZK7 | 3/20 | 0.39 |
| ▸ | PLA2G2D | Q9UNK4 | 3/20 | 0.39 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.39 |
| ▸ | PLA2G2F | Q9BZM2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704088 | 0.87 | PLA2G2A (0.42) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL14514453 | 0.76 | PLA2G2A (0.46) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL14339077 | 0.73 | GRK6 (0.48) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G5 | |
| SCHEMBL13485122 | 0.73 | PLA2G2A (0.41) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL13597693 | 0.73 | MAPT (0.42) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL13484866 | 0.69 | PLA2G2A (0.38) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL3187463 | 0.69 | PLA2G2A (0.77) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL13484713 | 0.68 | PLA2G2A (0.42) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL13597690 | 0.67 | PLA2G2A (0.71) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL31089727 | 0.65 | PLA2G2A (0.51) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951315-A2 | PHOSPHOLIPASE INHIBITORS, INCLUDING MULTI-VALENT PHOSPHOLIPASE INHIBITORS, AND USE THEREOF, INCLUDING AS LUMEN-LOCALIZED PHOSPHOLIPASE INHIBITORS | Ilypsa, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056279-A2 | PHOSPHOLIPASE INHIBITORS, INCLUDING MULTI-VALENT PHOSPHOLIPASE INHIBITORS, AND USE THEREOF, INCLUDING AS LUMEN-LOCALIZED PHOSPHOLIPASE INHIBITORS | ILYPSA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |