Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | LYN | P07948 | 3/20 | 0.38 |
| ▸ | HCK | P08631 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3571787 | 0.85 | KDR (0.48) | KDRFGFR1NTRK1NTRK3SRC | |
| SCHEMBL3571783 | 0.85 | KDR (0.48) | KDRFGFR1NTRK1NTRK3SRC | |
| SCHEMBL13255716 | 0.85 | KDR (0.44) | KDRFGFR1NTRK1NTRK3RET | |
| SCHEMBL3579266 | 0.84 | HTR7 (0.45) | KDRFGFR1NTRK1NTRK3RET | |
| SCHEMBL3577933 | 0.83 | KDR (0.46) | KDRFGFR1NTRK1SRCNTRK2 | |
| SCHEMBL3577932 | 0.83 | KDR (0.46) | KDRFGFR1NTRK1SRCNTRK2 | |
| SCHEMBL3579269 | 0.83 | HTR7 (0.39) | KDRFGFR1NTRK1NTRK3RET | |
| SCHEMBL3575229 | 0.82 | KDR (0.44) | KDRFGFR1NTRK1SRCNTRK2 | |
| SCHEMBL3575231 | 0.82 | KDR (0.44) | KDRFGFR1NTRK1SRCNTRK2 | |
| SCHEMBL3572738 | 0.82 | KDR (0.45) | KDRFGFR1NTRK1SRCNTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902025-A1 | KINASE INHIBITORS | Allergan, Inc. (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | claimed |