Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 8/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705619 | 0.94 | TACR1 (0.36) | TACR1EPAS1GPBAR1TP53MAPT | |
| SCHEMBL4705059 | 0.92 | TACR1 (0.36) | TACR1EPAS1GPBAR1TP53MAPT | |
| SCHEMBL4705246 | 0.91 | TACR1 (0.36) | TACR1EPAS1GPBAR1TP53MAPT | |
| SCHEMBL4707071 | 0.90 | TACR1 (0.40) | TACR1EPAS1GPBAR1TP53MAPT | |
| SCHEMBL4637972 | 0.89 | ALDH1A1 (0.44) | TACR1GRM2ALDH1A1 | |
| SCHEMBL4707521 | 0.88 | TACR1 (0.37) | TACR1EPAS1GPBAR1TP53MAPT | |
| SCHEMBL4638055 | 0.87 | ALDH1A1 (0.38) | TACR1GPBAR1GRM2ALDH1A1 | |
| SCHEMBL4708547 | 0.86 | GRM2 (0.37) | TACR1GPBAR1GRM2KDM4EALDH1A1 | |
| SCHEMBL4639432 | 0.86 | AVPR2 (0.34) | TACR1EPAS1GPBAR1TP53MAPT | |
| SCHEMBL4708316 | 0.85 | TACR1 (0.33) | TACR1EPAS1TP53MAPTGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-A1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-02-02 | — | — | EP | claimed |
| WO-2003091226-A1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2003-11-06 | — | — | WO | claimed |
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |