SCHEMBL4758450

SCHEMBL4758450

O=C(OCc1ccccc1)OC(=O)C1CCCN1

nearest known ligand 0.51

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.51
HTR2C P28335 1/20 0.51
HTR2B P41595 1/20 0.51
CTSC P53634 1/20 0.44
ELANE P08246 1/20 0.43
GLA P06280 1/20 0.42
ALDH1A1 P00352 4/20 0.42
GAA P10253 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3447413 1.00 TSHR (0.51) TSHRHTR2CHTR2BCTSCELANE
SCHEMBL489770 1.00 TSHR (0.51) TSHRHTR2CHTR2BCTSCELANE
SCHEMBL7412066 0.93 TSHR (0.48) TSHRHTR2CHTR2BGLAALDH1A1
SCHEMBL11425268 0.92 HTR2C (0.45) TSHRHTR2CHTR2BCTSCELANE
SCHEMBL4069956 0.89 TSHR (0.63) TSHRHTR2CHTR2BCTSCELANE
SCHEMBL630517 0.89 TSHR (0.63) TSHRHTR2CHTR2BCTSCELANE
SCHEMBL693351 0.89 TSHR (0.63) TSHRHTR2CHTR2BCTSCELANE
Hydrochloric Acid SCHEMBL1000787 0.87 TSHR (0.65) TSHRHTR2CHTR2BCTSCELANE
Hydrochloric Acid SCHEMBL630516 0.87 TSHR (0.65) TSHRHTR2CHTR2BCTSCELANE
Hydrochloric Acid SCHEMBL693350 0.87 TSHR (0.65) TSHRHTR2CHTR2BCTSCELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2951185-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF Aptinyx Inc. (US) 2015-12-09 EP disclosed
EP-2771021-A2 NMDA RECEPTOR MODULATORS AND USES THEREOF North Western University (US) 2014-09-03 EP disclosed
WO-2014120800-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF NAUREX, INC. (US) 2014-08-07 WO disclosed
WO-2013063120-A2 NMDA RECEPTOR MODULATORS AND USES THEREOF NORTHWESTERN UNIVERSITY (US) 2013-05-02 WO disclosed
WO-2008011557-A2 HETEROARYL INHIBITORS OF RHO KINASE BORCHARDT ALLEN J (US) 2008-01-24 WO disclosed