Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.46 |
| ▸ | RELA | Q04206 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL218887 | 0.82 | RAB9A (0.68) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL13470765 | 0.81 | KDM4E (0.64) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL12167514 | 0.79 | APP (0.50) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL26833294 | 0.78 | RAB9A (0.51) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL23458521 | 0.77 | NPC1 (0.68) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL220051 | 0.77 | APP (0.51) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL26535849 | 0.75 | RAB9A (0.46) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4759004 | 0.73 | NPC1 (0.45) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL2740222 | 0.72 | MAPT (0.53) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL2740073 | 0.72 | MAPT (0.57) | RAB9ANPC1KDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910380-A1 | OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019417-A1 | OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |