Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 12/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 11/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 11/20 | 0.58 |
| ▸ | PTGIR | P43119 | 4/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4759817 | 0.81 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CPTGIRCYP2D6 | |
| SCHEMBL13017196 | 0.81 | ADRA2A (0.81) | ADRA2AADRA2BADRA2CPTGIRGPR65 | |
| Hydrochloric Acid SCHEMBL6161690 | 0.80 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CPTGIRGPR65 | |
| SCHEMBL7081326 | 0.80 | PTGIR (0.55) | ADRA2AADRA2BADRA2CPTGIRGPR65 | |
| SCHEMBL5803363 | 0.78 | PTGIR (0.77) | ADRA2AADRA2BADRA2CPTGIR | |
| SCHEMBL4743095 | 0.78 | ADRA2A (0.66) | ADRA2AADRA2BADRA2CPTGIRGPR65 | |
| SCHEMBL13063330 | 0.76 | CYP2D6 (0.58) | ADRA2AADRA2BADRA2CPTGIRCYP2D6 | |
| SCHEMBL13017193 | 0.76 | ADRA2A (0.88) | ADRA2AADRA2BADRA2CPTGIRCYP2D6 | |
| SCHEMBL13062961 | 0.76 | ADRA2A (0.72) | ADRA2AADRA2BADRA2CPTGIRGPR65 | |
| Hydrochloric Acid SCHEMBL4689790 | 0.75 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CPTGIRGPR65 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981498-A2 | USE OF 2-IMIDAZOLES FOR THE TREATMENT OF CNS DISORDERS | F. Hoffmann-la Roche AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007090720-A2 | USE OF 2-IMIDAZOLES FOR THE TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-16 | — | — | WO | disclosed |