Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.38 |
| ▸ | F11 | P03951 | 15/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4759707 | 0.83 | SLC1A3 (0.36) | AAK1F11KLKB1 | |
| SCHEMBL1197231 | 0.83 | F11 (0.46) | AAK1F11KLKB1 | |
| SCHEMBL1197235 | 0.83 | F11 (0.46) | AAK1F11KLKB1 | |
| SCHEMBL19488575 | 0.67 | AAK1 (0.43) | AAK1 | |
| SCHEMBL1197065 | 0.66 | F11 (0.53) | AAK1F11KLKB1 | |
| SCHEMBL1196625 | 0.66 | F11 (0.69) | F11KLKB1 | |
| SCHEMBL17494049 | 0.66 | AAK1 (0.49) | AAK1 | |
| SCHEMBL17494050 | 0.66 | AAK1 (0.49) | AAK1 | |
| SCHEMBL1196771 | 0.66 | F11 (0.49) | F11KLKB1 | |
| SCHEMBL1196772 | 0.66 | F11 (0.49) | F11KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981854-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007070826-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |