Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL854697 | 0.82 | JAK3 (0.47) | JAK3ALDH1A1GAAKDM4EMAPT | |
| SCHEMBL27696590 | 0.81 | P4HTM (0.40) | JAK3GAAKDM4EMAPTLMNA | |
| SCHEMBL4760140 | 0.80 | NPC1 (0.34) | JAK3ALDH1A1GAAKDM4EMAPT | |
| SCHEMBL13341001 | 0.76 | HTT (0.50) | ALDH1A1 | |
| SCHEMBL4758869 | 0.73 | LMNA (0.61) | ALDH1A1KDM4EMAPTLMNAPOLB | |
| SCHEMBL4758882 | 0.73 | JAK2 (0.41) | ALDH1A1MAPTACHEJAK2JAK1 | |
| SCHEMBL1845562 | 0.71 | MAPT (0.48) | ALDH1A1GAAKDM4EMAPTLMNA | |
| SCHEMBL12695029 | 0.70 | RRM2 (0.46) | ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL3639381 | 0.69 | GAA (0.46) | ALDH1A1GAAKDM4EMAPTLMNA | |
| SCHEMBL1845515 | 0.69 | NPC1 (0.51) | ALDH1A1GAAKDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194640-A1 | Optically Active Tetrahydronaphthalene Derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-08-14 | — | — | US | claimed |
| EP-1852431-A1 | OPTICALLY ACTIVE TETRAHYDRONAPHTHALENE DERIVATIVE | MITSUBISHI PHARMA CORPORATION (JP) | 2007-11-07 | — | — | EP | claimed |
| US-20080194640-A1 | Optically Active Tetrahydronaphthalene Derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-08-14 | — | — | US | disclosed |
| US-20080194640-A1 | Optically Active Tetrahydronaphthalene Derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-08-14 | — | — | US | disclosed |
| EP-1852431-A1 | OPTICALLY ACTIVE TETRAHYDRONAPHTHALENE DERIVATIVE | MITSUBISHI PHARMA CORPORATION (JP) | 2007-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194640-A1 | Optically Active Tetrahydronaphthalene Derivative | C3AR1, C5AR1, C5AR2 | JAK3 3795/4885ALDH1A1 1551/4885GAA 4733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.