Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ULK1 | O75385 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.43 |
| ▸ | SELE | P16581 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | BCL3 | P20749 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2420481 | 0.84 | CD274 (0.56) | CD274EPHX2HTR3ASMN1; SMN2PARP1 | |
| SCHEMBL2416784 | 0.76 | ALDH1A1 (0.59) | CD274EPHX2HTR3ASMN1; SMN2HPGD | |
| SCHEMBL2417659 | 0.76 | ALDH1A1 (0.53) | CD274HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL2416065 | 0.76 | ALDH1A1 (0.56) | CD274EPHX2SMN1; SMN2HPGDKDM4E | |
| SCHEMBL2421223 | 0.75 | ALDH1A1 (0.50) | CD274EPHX2SMN1; SMN2HPGDKDM4E | |
| SCHEMBL2412603 | 0.75 | BCL3 (0.61) | SMN1; SMN2HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL2416429 | 0.74 | ALDH1A1 (0.58) | CD274HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL18108692 | 0.73 | CD274 (0.56) | CD274EPHX2HTR3ASMN1; SMN2HPGD | |
| SCHEMBL2615238 | 0.73 | CD274 (0.92) | CD274EPHX2SMN1; SMN2HPGDKDM4E | |
| SCHEMBL2615239 | 0.73 | CD274 (0.92) | CD274EPHX2SMN1; SMN2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530573-B1 | CONDENSED HETEROCYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-03-19 | — | — | EP | claimed |