Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Valproic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.94 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.94 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.94 |
| ▸ | HTR2A | P28223 | 1/20 | 0.94 |
| ▸ | HTR2C | P28335 | 1/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.94 |
| ▸ | HRH1 | P35367 | 1/20 | 0.94 |
| ▸ | DRD3 | P35462 | 1/20 | 0.94 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.94 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.94 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.94 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.60 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.60 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.60 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.60 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valproic Acid SCHEMBL140241 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL2275 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL1330837 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL6910916 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL7579608 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL139238 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL1738242 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL1311803 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL69795 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL21378840 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111333926-B | Low-temperature-resistant compression permanent deformation damping rubber and preparation method thereof | 株洲时代新材料科技股份有限公司 | 2022-08-16 | — | — | CN | claimed |
| CN-111333926-A | Low-temperature-resistant compression permanent deformation damping rubber and preparation method thereof | 株洲时代新材料科技股份有限公司 | 2020-06-26 | — | — | CN | claimed |
| US-7833546-B2 | Pharmaceutical dosage form and method for the production thereof | EVONIK ROEHM GMBH (DE) | 2010-11-16 | — | — | US | claimed |
| CN-1697649-B | Dosage form and method for producing the same | ROEHM GMBH | 2010-05-12 | — | — | CN | claimed |
| EP-1496870-B1 | DOSAGE FORM AND METHOD FOR PRODUCING THE SAME | EVONIK ROEHM GMBH (DE) | 2009-09-02 | — | — | EP | claimed |
| EP-1478352-B1 | PHARMACEUTICAL DOSAGE FORM AND METHOD FOR THE PRODUCTION THEREOF | ROEHM GMBH (DE) | 2006-08-16 | — | — | EP | claimed |
| CN-1697649-A | Dosage form and method for producing the same | ROEHM GMBH (DE) | 2005-11-16 | — | — | CN | claimed |
| US-20050152977-A1 | Dosage form and method for producing the same | ROEHM GMBH (DE) | 2005-07-14 | — | — | US | claimed |
| US-20050079216-A1 | Pharmaceutical dosage form and method for the production thereof | ROEHM GMBH & CO. KG (DE) | 2005-04-14 | — | — | US | claimed |
| CN-111333926-B | Low-temperature-resistant compression permanent deformation damping rubber and preparation method thereof | 株洲时代新材料科技股份有限公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-111333926-A | Low-temperature-resistant compression permanent deformation damping rubber and preparation method thereof | 株洲时代新材料科技股份有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-102361635-B | Coated solid preparation | TORAY INDUSTRIES, INC. (JP) | 2016-11-30 | — | — | CN | disclosed |
| EP-2412369-B1 | COATED SOLID PREPARATION | TORAY INDUSTRIES (JP) | 2016-08-31 | — | — | EP | disclosed |
| US-8652521-B2 | Coated solid preparation | TORAY INDUSTRIES, INC. (JP) | 2014-02-18 | — | — | US | disclosed |
| US-7833546-B2 | Pharmaceutical dosage form and method for the production thereof | EVONIK ROEHM GMBH (DE) | 2010-11-16 | — | — | US | disclosed |
| CN-1697649-B | Dosage form and method for producing the same | ROEHM GMBH | 2010-05-12 | — | — | CN | disclosed |
| US-7498044-B2 | Dosage form and method for producing the same | ROEHM GMBH & CO. KG (DE) | 2009-03-03 | — | — | US | disclosed |
| CN-1697649-A | Dosage form and method for producing the same | ROEHM GMBH (DE) | 2005-11-16 | — | — | CN | disclosed |
| US-20050152977-A1 | Dosage form and method for producing the same | ROEHM GMBH (DE) | 2005-07-14 | — | — | US | disclosed |
| US-20050079216-A1 | Pharmaceutical dosage form and method for the production thereof | ROEHM GMBH & CO. KG (DE) | 2005-04-14 | — | — | US | disclosed |