Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979362 | 0.83 | MEN1 (0.46) | SCN5ASCN9AHDAC1HDAC8HDAC6 | |
| SCHEMBL3728320 | 0.83 | XIAP (0.51) | SCN5ASCN9AHDAC1HDAC8HDAC6 | |
| SCHEMBL6099116 | 0.83 | SMN1; SMN2 (0.46) | SCN5ASCN9AHDAC1HDAC8HDAC6 | |
| SCHEMBL6099121 | 0.83 | SMN1; SMN2 (0.46) | SCN5ASCN9AHDAC1HDAC8HDAC6 | |
| SCHEMBL15676882 | 0.83 | HDAC1 (0.46) | SCN5ASCN9AHDAC1HDAC8HDAC6 | |
| SCHEMBL4979370 | 0.83 | MEN1 (0.46) | SCN5ASCN9AHDAC1HDAC8HDAC6 | |
| SCHEMBL4884804 | 0.83 | GRIN2B (0.45) | SCN5ASCN9AHDAC1HDAC8HDAC6 | |
| SCHEMBL1196006 | 0.83 | MEN1 (0.51) | SCN5ASCN9AHDAC1HDAC8HDAC6 | |
| SCHEMBL1196005 | 0.83 | MEN1 (0.51) | SCN5ASCN9AHDAC1HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL8582025 | 0.82 | MEN1 (0.50) | SCN5ASCN9AHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899339-A1 | 1,2-DIHYDRO-SPIRO(3H-INDOLE-3-4 -PIPERIDINE) COMPOUNDS AS MODULATORS OF THE MAS RECEPTOR NOVEL | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007002114-A1 | 1,2-DIHYDRO-SPIRO(3H-INDOLE-3-4’-PIPERIDINE) COMPOUNDS AS MODULATORS OF THE MAS RECEPTOR NOVEL | ARENA PHARMACEUTICALS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |