Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.48 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1549039 | 0.87 | LMNA (0.49) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL1548187 | 0.83 | LMNA (0.52) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL1548830 | 0.81 | SPHK2 (0.69) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL1548196 | 0.78 | LMNA (0.48) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2734558 | 0.76 | LMNA (0.48) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL4995901 | 0.75 | SPHK2 (0.46) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL4718400 | 0.72 | MEN1 (0.51) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL4995897 | 0.71 | SPHK2 (0.42) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL4717890 | 0.71 | MEN1 (0.50) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL4718166 | 0.71 | LMNA (0.66) | LMNAMEN1KMT2AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904439-A2 | SPHINGOSINE KINASE INHIBITORS | Apogee Biothechnology Corporation (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006138660-A2 | SPHINGOSINE KINASE INHIBITORS | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2006-12-28 | — | — | WO | disclosed |