Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | BACE1 | P56817 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 12/20 | 0.52 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5356821 | 0.96 | ACHE (0.53) | ACHEBACE1PDGFRBMAPK7PDGFRA | |
| SCHEMBL4761417 | 0.91 | ACHE (0.54) | ACHEBACE1PDGFRBMAPK7PDGFRA | |
| SCHEMBL4762558 | 0.88 | MAPK7 (0.54) | ACHEBACE1PDGFRBMAPK7PDGFRA | |
| SCHEMBL4761392 | 0.87 | ENPP1 (0.50) | ACHEBACE1PDGFRBMAPK7PDGFRA | |
| Trifluoroacetic Acid SCHEMBL4762554 | 0.86 | MAPK7 (0.53) | ACHEBACE1PDGFRBMAPK7PDGFRA | |
| SCHEMBL5463718 | 0.85 | ENPP1 (0.51) | ACHEBACE1PDGFRBPDGFRAKIT | |
| SCHEMBL8247200 | 0.84 | ACHE (0.47) | ACHEBACE1PDGFRBMAPK7PDGFRA | |
| Formic Acid SCHEMBL5467581 | 0.84 | ENPP1 (0.49) | ACHEBACE1PDGFRBMAPK7PDGFRA | |
| Formic Acid SCHEMBL5464379 | 0.83 | ENPP1 (0.50) | ACHEBACE1PDGFRBPDGFRAKIT | |
| SCHEMBL4761451 | 0.83 | ACHE (0.67) | ACHEBACE1KITENPP1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940819-A1 | PHOSPHODIESTERASE 10 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| US-7268142-B2 | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline | PFIZER INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268142-B2 | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline | PFIZER INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268142-B2 | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline | PFIZER INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-20070093515-A1 | Phosphodiesterase 10 inhibitors | AMGEN INC. | 2007-04-26 | — | — | US | disclosed |
| WO-2007022280-A1 | PHOSPHODIESTERASE 10 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |
| US-20050182079-A1 | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline | PFIZER INC | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182079-A1 | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline | PDE5A, PDE3A, PDE3B | ACHE 20/4885BACE1 570/4885PDGFRB 3233/4885 |
| US-20070093515-A1 | Phosphodiesterase 10 inhibitors | PDE7A, PDE12, PDE10A | ACHE 66/4885BACE1 707/4885PDGFRB 3731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.