Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 15/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4276267 | 0.95 | NR3C1 (0.50) | NR3C1CYP11B1CYP11B2MAPTALDH1A1 | |
| SCHEMBL4276148 | 0.88 | NR3C1 (0.48) | NR3C1CYP11B1CYP11B2 | |
| SCHEMBL4278755 | 0.87 | NR3C1 (0.52) | NR3C1CYP11B1CYP11B2 | |
| SCHEMBL4283300 | 0.87 | NR3C1 (0.60) | NR3C1 | |
| SCHEMBL4280464 | 0.86 | NR3C1 (0.56) | NR3C1CYP11B1CYP11B2 | |
| SCHEMBL4274871 | 0.86 | NR3C1 (0.48) | NR3C1CYP11B1CYP11B2 | |
| SCHEMBL4273810 | 0.85 | NR3C1 (0.52) | NR3C1CYP11B1CYP11B2 | |
| SCHEMBL4280389 | 0.84 | NR3C1 (0.48) | NR3C1CYP11B1CYP11B2 | |
| SCHEMBL4273944 | 0.84 | NR3C1 (0.49) | NR3C1CYP11B1CYP11B2 | |
| SCHEMBL4280449 | 0.83 | NR3C1 (0.52) | NR3C1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893588-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006135826-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-21 | — | — | WO | claimed |