Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 10/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2744399 | 0.84 | KCNH2 (0.44) | KCNH2ATMATRMAPTPOLB | |
| SCHEMBL1140827 | 0.80 | MAPT (0.39) | KCNH2MAPTPOLBMCL1SMN1; SMN2 | |
| SCHEMBL13914462 | 0.78 | MAPT (0.47) | KCNH2MAPTPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL13914461 | 0.78 | PDE10A (0.43) | KCNH2MAPTPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL25262335 | 0.78 | KCNH2 (0.37) | KCNH2ATMATRCYP2C9PRKCQ | |
| SCHEMBL31025949 | 0.78 | KCNH2 (0.37) | KCNH2ATMATRCYP2C9PRKCQ | |
| SCHEMBL12744372 | 0.76 | MAPT (0.46) | MAPTPOLBSMN1; SMN2L3MBTL1PDE10A | |
| SCHEMBL2749823 | 0.76 | MAPT (0.57) | KCNH2MAPTPOLBSMN1; SMN2CYP2C9 | |
| SCHEMBL2113586 | 0.76 | PTGES (0.41) | KCNH2ATMATRPRKCQ | |
| SCHEMBL191477 | 0.75 | MAPT (0.48) | KCNH2MAPTPOLBSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968587-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | Coley Pharmaceutical, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007075468-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-07-05 | — | — | WO | disclosed |