⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL126931 | 0.67 | — | — | |
| SCHEMBL4316825 | 0.61 | PDPK1 (0.33) | — | |
| SCHEMBL6860721 | 0.59 | — | — | |
| SCHEMBL10123652 | 0.56 | KDM4E (0.38) | — | |
| SCHEMBL280067 | 0.56 | ESR1 (0.40) | — | |
| SCHEMBL21721617 | 0.56 | RAF1 (0.33) | — | |
| SCHEMBL2706397 | 0.56 | STS (0.36) | — | |
| SCHEMBL13400736 | 0.55 | PDPK1 (0.32) | — | |
| SCHEMBL280038 | 0.55 | ALDH1A1 (0.31) | — | |
| SCHEMBL140254 | 0.54 | POLB (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401738-A | Angiotensin antagonist, hypotensive, aldosteronism, cardiac insufficiency | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER (DE) | 1995-03-28 | — | — | US | claimed |
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1392657-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-03-10 | — | — | EP | disclosed |
| EP-1392657-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2003053331-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-07-03 | — | — | WO | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |
| EP-0702013-B1 | Imidazopyridines | MERCK PATENT GMBH (DE) | 2001-06-13 | — | — | EP | disclosed |
| EP-0496222-B1 | Indole derivatives | MERCK PATENT GMBH (DE) | 1998-09-09 | — | — | EP | disclosed |
| US-5684015-A | ANGIOTENSIN ANTAGONIST AS HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-11-04 | — | — | US | disclosed |
| EP-0300287-A2 | Process for the reduction of ketones | MERCK PATENT GmbH (DE) | 1989-01-25 | — | — | EP | disclosed |
| EP-0292800-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |
| EP-0286813-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1988-10-19 | — | — | EP | disclosed |
| EP-0284942-A2 | Amino-acid derivatives | MERCK PATENT GmbH (DE) | 1988-10-05 | — | — | EP | disclosed |
| US-4766213-A | 1,4-dihydropyridines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-08-23 | — | — | US | disclosed |
| EP-0272444-A2 | Renin-inhibiting peptides | MERCK PATENT GmbH (DE) | 1988-06-29 | — | — | EP | disclosed |
| EP-0264795-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1988-04-27 | — | — | EP | disclosed |
| EP-0262318-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1988-04-06 | — | — | EP | disclosed |
| EP-0249096-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1987-12-16 | — | — | EP | disclosed |
| EP-0237695-A2 | 1,4-Dihydropyridines | MERCK PATENT GmbH (DE) | 1987-09-23 | — | — | EP | disclosed |