Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 6/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL476417 | 0.91 | CNR1 (0.36) | CNR1CNR2 | |
| SCHEMBL476535 | 0.88 | CNR1 (0.40) | CNR1TP53MDM2CNR2KCNH2 | |
| SCHEMBL476233 | 0.88 | CNR1 (0.41) | CNR1TP53MDM2CNR2KCNH2 | |
| SCHEMBL2681971 | 0.84 | CNR1 (0.40) | CNR1TP53MDM2CNR2KCNH2 | |
| SCHEMBL2682774 | 0.83 | CNR1 (0.38) | CNR1TP53MDM2CNR2KCNH2 | |
| SCHEMBL2682999 | 0.83 | CNR1 (0.37) | CNR1TP53MDM2CNR2KCNH2 | |
| SCHEMBL2682522 | 0.83 | CNR1 (0.38) | CNR1TP53MDM2CNR2KCNH2 | |
| SCHEMBL2682539 | 0.82 | CNR1 (0.39) | CNR1TP53MDM2CNR2KCNH2 | |
| SCHEMBL6014240 | 0.81 | CNR1 (0.45) | CNR1TP53MDM2CNR2 | |
| SCHEMBL476384 | 0.81 | CNR1 (0.45) | CNR1TP53MDM2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411383-B1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-10-22 | — | — | EP | disclosed |
| US-8486971-B2 | Derivatives of 3-alkoxy-4,5-diarylthiophene-2-carboxamide, preparation thereof, and therapeutic use thereof | SANOFI (FR) | 2013-07-16 | — | — | US | disclosed |
| US-20120115906-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-05-10 | — | — | US | disclosed |
| EP-2411383-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109150-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115906-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | HRH4, HCRTR1, NR3C1 | CNR1 4/4885TP53 4362/4885MDM2 3969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.