Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.58 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.58 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.58 |
| ▸ | MYLK | Q15746 | 1/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.58 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.58 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10026437 | 0.81 | TSHR (0.51) | MAPK14MAPK9PRKD2PRKD3MAPKAPK2 | |
| SCHEMBL28777603 | 0.78 | PARP1 (0.43) | MAPK14MAPK9PRKD2PRKD3MAPKAPK2 | |
| SCHEMBL20883148 | 0.76 | MAPK14 (0.54) | MAPK14MAPK9PRKD2PRKD3MAPKAPK2 | |
| SCHEMBL12678038 | 0.76 | MAPK14 (0.59) | MAPK14MAPK9PRKD2PRKD3MAPKAPK2 | |
| SCHEMBL15324278 | 0.75 | MAPK11 (0.53) | MAPK14MAPK9PRKD2PRKD3MAPKAPK2 | |
| SCHEMBL30658173 | 0.75 | MAPK11 (0.53) | MAPK14MAPK9PRKD2PRKD3MAPKAPK2 | |
| SCHEMBL22764068 | 0.75 | MAPK14 (0.86) | MAPK14MAPK9PRKD2PRKD3MAPKAPK2 | |
| Vx-702 SCHEMBL185712 | 0.74 | MAPK14 (1.00) | MAPK14MAPK9PRKD2PRKD3MAPKAPK2 | |
| Vx-702 SCHEMBL29367579 | 0.74 | MAPK14 (1.00) | MAPK14MAPK9PRKD2PRKD3MAPKAPK2 | |
| SCHEMBL25308353 | 0.73 | PARP1 (0.43) | MAPK14MAPK9PRKD2PRKD3MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937682-A1 | MET KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007041379-A1 | MET KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-12 | — | — | WO | disclosed |