Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1608842 | 0.88 | TSHR (0.49) | TSHRMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL4762995 | 0.81 | MAPK14 (0.58) | MEN1KMT2AL3MBTL1TDP1PRKD3 | |
| SCHEMBL1610106 | 0.81 | POLB (0.47) | TSHRMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL2518297 | 0.81 | TSHR (0.43) | TSHRMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL9355979 | 0.80 | TSHR (0.55) | TSHRMEN1KMT2AMAPTHPGD | |
| SCHEMBL4428869 | 0.80 | TSHR (0.57) | TSHRMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL10060808 | 0.79 | PRKD3 (0.54) | TSHRMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL367075 | 0.79 | TSHR (0.57) | TSHRMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL12712568 | 0.78 | MAPK14 (0.74) | TSHRMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL23023732 | 0.76 | NPC1 (0.41) | TSHRKMT2AMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120316345-A1 | PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES) | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-12-13 | — | — | US | disclosed |
| US-8273896-B2 | Processes for producing phenyl-6-(1-(phenyl)ureido)nicotinamides | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2012-09-25 | — | — | US | disclosed |
| US-20120157684-A1 | PROCESSES FOR THE FACILE SYNTHESIS OF DIARYL AMINES AND ANALOGUES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-21 | — | — | US | disclosed |
| US-8034950-B2 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-10-11 | — | — | US | disclosed |
| US-20110086891-A1 | Solid Forms of 2-(2,4-Difluorophenyl)-6-(1-(2,6-Difluorophenyl)Ureido)Nicotinamide) | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-04-14 | — | — | US | disclosed |
| US-20100234606-A1 | PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES) | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-09-16 | — | — | US | disclosed |
| WO-2010093890-A2 | PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES) | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010093889-A2 | SOLID FORMS OF 2-(2, 4-DIFLUOROPHENYL)-6-(1-(2,6-DIFLUOROPHENYL)UREIDO)NICOTINAMIDE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-19 | — | — | WO | disclosed |
| US-20070173649-A1 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157684-A1 | PROCESSES FOR THE FACILE SYNTHESIS OF DIARYL AMINES AND ANALOGUES THEREOF | ABL1, PNMT, MAOA | TSHR 4555/4885MEN1 150/4885KMT2A 375/4885 |
| US-20100234606-A1 | PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES) | MAPK1, NADK, NAMPT | TSHR 4315/4885MEN1 3236/4885KMT2A 2811/4885 |
| US-20110086891-A1 | Solid Forms of 2-(2,4-Difluorophenyl)-6-(1-(2,6-Difluorophenyl)Ureido)Nicotinamide) | NNT, NAMPT, NNMT | TSHR 3467/4885MEN1 1272/4885KMT2A 1076/4885 |
| US-20070173649-A1 | Processes for the facile synthesis of diaryl amines and analogues thereof | ABL1, PNMT, MAOA | TSHR 4555/4885MEN1 150/4885KMT2A 375/4885 |
| US-20120316345-A1 | PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES) | MAPK1, NADK, NAMPT | TSHR 4315/4885MEN1 3236/4885KMT2A 2811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.