Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.57 |
| ▸ | RHOA | P61586 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27631863 | 0.89 | GPR119 (0.62) | GPR119RHOALMNATDP1CHRM4 | |
| SCHEMBL1673633 | 0.87 | GPR119 (0.77) | GPR119POLBALDH1A1MAPT | |
| SCHEMBL27631857 | 0.85 | GPR119 (0.62) | GPR119RHOALMNATDP1PDE10A | |
| SCHEMBL28757298 | 0.84 | GPR119 (0.67) | GPR119RHOALMNATDP1NEK2 | |
| SCHEMBL27747820 | 0.83 | GPR119 (0.79) | GPR119RHOALMNACHRM4ALDH1A1 | |
| SCHEMBL27652250 | 0.83 | GPR119 (0.60) | GPR119RHOAPOLBMAPT | |
| SCHEMBL5266383 | 0.82 | GPR119 (0.60) | GPR119CHRM4ALDH1A1MAPT | |
| SCHEMBL27631842 | 0.82 | GPR119 (0.70) | GPR119RHOALMNANEK2PDE10A | |
| SCHEMBL1070108 | 0.80 | GPR119 (0.79) | GPR119RHOALMNAPOLBPDE10A | |
| SCHEMBL27652119 | 0.79 | GPR119 (0.81) | GPR119RHOALMNANEK2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1927594-A1 | 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia | Arena Pharmaceuticals, Inc. (US) | 2008-06-04 | — | — | EP | disclosed |
| EP-1599468-B1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | ARENA PHARM INC (US) | 2007-10-03 | — | — | EP | disclosed |