Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR7 | P34969 | 2/20 | 0.31 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6492870 | 0.92 | CRHR1 (0.34) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4804115 | 0.88 | CRHR1 (0.41) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4763245 | 0.86 | CRHR1 (0.46) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4767150 | 0.86 | CRHR1 (0.43) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4762385 | 0.83 | CRHR1 (0.43) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4763067 | 0.81 | CRHR1 (0.43) | CRHR1GABRA2GABRB2DRD2HTR2A | |
| SCHEMBL4762104 | 0.81 | CRHR1 (0.43) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL13986668 | 0.81 | CRHR1 (0.42) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4763468 | 0.77 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL4767336 | 0.76 | CRHR1 (0.42) | CRHR1GABRA2GABRB2DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462622-B2 | Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin releasing factor antagonists | GLAXO GROUP LIMITED (GB) | 2008-12-09 | — | — | US | disclosed |
| EP-1395591-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-06-04 | — | — | EP | disclosed |