Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL476234 | 0.95 | TP53 (0.36) | TP53MDM2CNR1MAPTF10 | |
| SCHEMBL476352 | 0.88 | CNR1 (0.37) | TP53MDM2CNR1CHRM1CHRM3 | |
| SCHEMBL476386 | 0.87 | CNR1 (0.36) | TP53MDM2CNR1CHRM1CHRM3 | |
| SCHEMBL476431 | 0.84 | CNR1 (0.36) | TP53MDM2CNR1MAPT | |
| SCHEMBL476391 | 0.84 | CNR1 (0.39) | TP53MDM2CNR1MAPT | |
| SCHEMBL476266 | 0.84 | CNR1 (0.36) | TP53MDM2CNR1 | |
| SCHEMBL476375 | 0.84 | CNR1 (0.37) | TP53MDM2CNR1CHRM1CHRM3 | |
| SCHEMBL476316 | 0.83 | CNR1 (0.37) | TP53MDM2CNR1 | |
| SCHEMBL476225 | 0.83 | CNR1 (0.38) | TP53MDM2CNR1MAPTKDM4E | |
| SCHEMBL476343 | 0.82 | CNR1 (0.41) | TP53MDM2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411383-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-01 | — | — | EP | claimed |
| WO-2010109150-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | claimed |