Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 9/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL476266 | 0.98 | CNR1 (0.36) | CNR1TP53MDM2SMN1; SMN2CNR2 | |
| SCHEMBL476375 | 0.93 | CNR1 (0.37) | CNR1TP53MDM2SMN1; SMN2CNR2 | |
| SCHEMBL476352 | 0.92 | CNR1 (0.37) | CNR1TP53MDM2SMN1; SMN2CNR2 | |
| SCHEMBL476316 | 0.91 | CNR1 (0.37) | CNR1TP53MDM2SMN1; SMN2CNR2 | |
| SCHEMBL476386 | 0.91 | CNR1 (0.36) | CNR1TP53MDM2SMN1; SMN2CNR2 | |
| SCHEMBL476391 | 0.86 | CNR1 (0.39) | CNR1TP53MDM2MAPT | |
| SCHEMBL476234 | 0.85 | TP53 (0.36) | CNR1TP53MDM2MAPT | |
| SCHEMBL476225 | 0.84 | CNR1 (0.38) | CNR1TP53MDM2MAPT | |
| SCHEMBL476345 | 0.84 | TP53 (0.37) | CNR1TP53MDM2MAPT | |
| SCHEMBL476410 | 0.83 | PRKAB2 (0.35) | CNR1PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411383-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-01 | — | — | EP | claimed |
| WO-2010109150-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | claimed |