Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 7/20 | 0.53 |
| ▸ | EDNRA | P25101 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766620 | 0.90 | EDNRB (0.51) | EDNRBEDNRAKMT2AMEN1ATM | |
| SCHEMBL4591747 | 0.83 | EDNRB (0.61) | EDNRBEDNRATSHRMAPTSERPINE1 | |
| SCHEMBL4592011 | 0.83 | EDNRB (0.52) | EDNRBEDNRAKMT2AMEN1KDM4E | |
| SCHEMBL4591054 | 0.81 | EDNRA (0.52) | EDNRBEDNRA | |
| SCHEMBL4591686 | 0.80 | EDNRB (0.51) | EDNRBEDNRAMAPTTP53 | |
| SCHEMBL4592327 | 0.79 | EDNRA (0.50) | EDNRBEDNRA | |
| SCHEMBL4592550 | 0.78 | KMT2A (0.50) | EDNRBEDNRAKMT2AKDM4EALDH1A1 | |
| SCHEMBL4591811 | 0.78 | EDNRB (0.49) | EDNRBEDNRAKMT2AKDM4EALDH1A1 | |
| SCHEMBL9438048 | 0.78 | EDNRA (0.52) | EDNRBEDNRAKMT2AATMKDM4E | |
| SCHEMBL9318678 | 0.77 | MEN1 (0.44) | EDNRBEDNRAKMT2AMEN1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287469-A1 | Phosphoinositide 3-Kinase Inhibitors for Inhibiting Leukocyte Accumulation | DIACOVO THOMAS G | 2008-11-20 | — | — | US | claimed |
| EP-1885356-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR INHIBITING LEUKOCYTE ACCUMULATION | ICOS CORPORATION (US) | 2008-02-13 | — | — | EP | claimed |
| WO-2006089106-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR INHIBITING LEUKOCYTE ACCUMULATION | ICOS CORPORATION (US) | 2006-08-24 | — | — | WO | claimed |
| US-7074814-B2 | 3-substituted indoles and derivatives thereof as therapeutic agents | WARNER-LAMBERT COMPANY LLC (US) | 2006-07-11 | — | — | US | claimed |
| EP-1644360-A1 | 3-SUBSTITUTED INDOLES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | Warner-Lambert Company LLC (US) | 2006-04-12 | — | — | EP | claimed |
| US-20050004195-A1 | 3-Substituted indoles and derivatives thereof as therapeutic agents | PARA KIMBERLY SUZANNE (US) | 2005-01-06 | — | — | US | claimed |
| WO-2004108708-A1 | 3-SUBSTITUTED INDOLES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-12-16 | — | — | WO | claimed |
| US-20080287469-A1 | Phosphoinositide 3-Kinase Inhibitors for Inhibiting Leukocyte Accumulation | DIACOVO THOMAS G | 2008-11-20 | — | — | US | disclosed |
| EP-1885356-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR INHIBITING LEUKOCYTE ACCUMULATION | ICOS CORPORATION (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006089106-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR INHIBITING LEUKOCYTE ACCUMULATION | ICOS CORPORATION (US) | 2006-08-24 | — | — | WO | disclosed |
| US-7074814-B2 | 3-substituted indoles and derivatives thereof as therapeutic agents | WARNER-LAMBERT COMPANY LLC (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1644360-A1 | 3-SUBSTITUTED INDOLES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | Warner-Lambert Company LLC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-20050004195-A1 | 3-Substituted indoles and derivatives thereof as therapeutic agents | PARA KIMBERLY SUZANNE (US) | 2005-01-06 | — | — | US | disclosed |
| WO-2004108708-A1 | 3-SUBSTITUTED INDOLES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004195-A1 | 3-Substituted indoles and derivatives thereof as therapeutic agents | IDO1, TPH1, IDO2 | EDNRB 500/4885EDNRA 157/4885KMT2A 2610/4885 |
| US-20080287469-A1 | Phosphoinositide 3-Kinase Inhibitors for Inhibiting Leukocyte Accumulation | PI4KB, PIK3CA, PI4KA | EDNRB 1628/4885EDNRA 1595/4885KMT2A 3296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.