Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12908875 | 0.69 | ALDH1A1 (0.34) | ALDH1A1HSD17B10MAPTALOX15GAA | |
| SCHEMBL937742 | 0.69 | BPTF (0.42) | BPTFALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL9748593 | 0.66 | MAPK1 (0.50) | BPTFALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL19474937 | 0.64 | ALDH1A1 (0.47) | BPTFALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL620749 | 0.61 | BPTF (1.00) | BPTFALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL9748738 | 0.61 | MAPK1 (0.45) | BPTFALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL9901226 | 0.61 | BPTF (0.43) | BPTFALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL1719516 | 0.60 | ALDH1A1 (1.00) | BPTFALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL31381502 | 0.60 | BPTF (0.96) | BPTFALDH1A1HSD17B10MAPTALOX15 | |
| SCHEMBL12057602 | 0.60 | MAPT (0.37) | ALDH1A1HSD17B10MAPTALOX15GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432715-B1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-03-19 | — | — | EP | disclosed |
| US-7312224-B2 | Pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2007-12-25 | — | — | US | disclosed |
| US-20040242595-A1 | Pyrimidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2004-12-02 | — | — | US | disclosed |
| EP-1432715-A2 | PYRIMIDINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003031447-A2 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2003-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242595-A1 | Pyrimidine derivatives | TYMP, DPYD, TYMS | BPTF 4283/4885ALDH1A1 671/4885HSD17B10 2095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.