Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | UGCG | Q16739 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722664 | 0.92 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DALPL | |
| SCHEMBL4722532 | 0.91 | NOTUM (0.39) | PDE4APDE4BPDE4CPDE4DALPL | |
| SCHEMBL4723724 | 0.90 | GRIA2 (0.42) | PDE4APDE4BPDE4CPDE4DALPL | |
| SCHEMBL4718847 | 0.89 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DKIF11 | |
| SCHEMBL4721150 | 0.88 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL4723271 | 0.87 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DALPL | |
| SCHEMBL4719764 | 0.86 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DALPL | |
| SCHEMBL4720223 | 0.86 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DALPL | |
| SCHEMBL4719190 | 0.85 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DALPL | |
| SCHEMBL4724138 | 0.85 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |