Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 15/20 | 0.53 |
| ▸ | CTSL | P07711 | 6/20 | 0.40 |
| ▸ | CTSS | P25774 | 4/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212611 | 1.00 | CTSK (0.53) | CTSKCTSLCTSSCTSBKLK7 | |
| SCHEMBL6242917 | 1.00 | CTSK (0.53) | CTSKCTSLCTSSCTSBKLK7 | |
| SCHEMBL4315826 | 0.88 | CTSK (0.62) | CTSKCTSLCTSSCTSBMAPK1 | |
| SCHEMBL4315832 | 0.88 | CTSK (0.62) | CTSKCTSLCTSSCTSBMAPK1 | |
| SCHEMBL4328791 | 0.88 | CTSK (0.62) | CTSKCTSLCTSSCTSBMAPK1 | |
| SCHEMBL4328786 | 0.88 | CTSK (0.62) | CTSKCTSLCTSSCTSBMAPK1 | |
| SCHEMBL4309653 | 0.88 | CTSK (0.62) | CTSKCTSLCTSSCTSBMAPK1 | |
| SCHEMBL4309648 | 0.88 | CTSK (0.62) | CTSKCTSLCTSSCTSBMAPK1 | |
| SCHEMBL6580495 | 0.79 | CTSK (0.77) | CTSKCTSLCTSSCTSBMAPK1 | |
| SCHEMBL6741712 | 0.77 | CTSK (0.50) | CTSKCTSLCTSSCTSBKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |