Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.64 |
| ▸ | NOS3 | P29474 | 5/20 | 0.48 |
| ▸ | NOS2 | P35228 | 5/20 | 0.48 |
| ▸ | NOS1 | P29475 | 4/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 2/20 | 0.37 |
| ▸ | GABRD | O14764 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.37 |
| ▸ | GABRE | P78334 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31524301 | 0.86 | PDPK1 (0.56) | PDPK1NOS3NOS2NOS1PIK3CB | |
| SCHEMBL29959357 | 0.86 | PDPK1 (0.56) | PDPK1NOS3NOS2NOS1PIK3CB | |
| SCHEMBL20949819 | 0.85 | PDPK1 (0.50) | PDPK1NOS3NOS2NOS1PIK3CB | |
| SCHEMBL557742 | 0.82 | PDPK1 (0.52) | PDPK1NOS3NOS2NOS1PIK3CB | |
| SCHEMBL557986 | 0.82 | NOS3 (0.62) | PDPK1NOS3NOS2NOS1PIK3CB | |
| SCHEMBL14627579 | 0.80 | PDPK1 (0.61) | PDPK1NOS3NOS2NOS1PIK3CB | |
| Isoquinolin-3-Amine SCHEMBL177520 | 0.78 | PDPK1 (1.00) | PDPK1NOS3NOS2NOS1PIK3CB | |
| Isoquinolin-3-Amine SCHEMBL30378027 | 0.78 | PDPK1 (1.00) | PDPK1NOS3NOS2NOS1PIK3CB | |
| Isoquinolin-3-Amine SCHEMBL29975748 | 0.78 | PDPK1 (1.00) | PDPK1NOS3NOS2NOS1PIK3CB | |
| SCHEMBL19049156 | 0.78 | PDPK1 (0.59) | PDPK1PIK3CBABL1KDM4EHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963321-A2 | DIBENZONAPHTHYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007070319-A2 | DIBENZONAPHTHYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | WYETH (US) | 2007-06-21 | — | — | WO | claimed |