Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29943640 | 0.86 | CSNK1A1 (0.50) | SMN1; SMN2KDM4EALDH1A1TSHRHPGD | |
| SCHEMBL26101400 | 0.86 | CSNK1A1 (0.50) | SMN1; SMN2KDM4EALDH1A1TSHRHPGD | |
| SCHEMBL29631702 | 0.84 | CSNK1A1 (0.49) | SMN1; SMN2KDM4EALDH1A1TSHRHPGD | |
| SCHEMBL24477792 | 0.84 | CSNK1A1 (0.49) | SMN1; SMN2KDM4EALDH1A1TSHRHPGD | |
| SCHEMBL4768951 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2KDM4EALDH1A1TSHRHPGD | |
| SCHEMBL4766001 | 0.82 | POLB (0.52) | SMN1; SMN2KDM4EALDH1A1TSHRHPGD | |
| SCHEMBL4770277 | 0.82 | KDM4E (0.43) | SMN1; SMN2KDM4ETSHRHPGDCSNK1A1 | |
| SCHEMBL4770618 | 0.81 | ABL1 (0.51) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL21815333 | 0.80 | ABL1 (0.44) | SMN1; SMN2KDM4EKMT2AMEN1CSNK1A1 | |
| SCHEMBL1491746 | 0.79 | SMN1; SMN2 (0.71) | SMN1; SMN2HRH4ABL1BCRHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |