Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765249 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2CSNK1A1CLK4ABL1BCR | |
| SCHEMBL29943640 | 0.82 | CSNK1A1 (0.50) | SMN1; SMN2CSNK1A1CLK4MAPTPIN1 | |
| SCHEMBL26101400 | 0.82 | CSNK1A1 (0.50) | SMN1; SMN2CSNK1A1CLK4MAPTPIN1 | |
| SCHEMBL24477792 | 0.81 | CSNK1A1 (0.49) | SMN1; SMN2CSNK1A1CLK4MAPTKDM4E | |
| SCHEMBL29631702 | 0.81 | CSNK1A1 (0.49) | SMN1; SMN2CSNK1A1CLK4MAPTKDM4E | |
| SCHEMBL4766001 | 0.78 | POLB (0.52) | SMN1; SMN2CSNK1A1CLK4MAPTKDM4E | |
| SCHEMBL4770618 | 0.77 | ABL1 (0.51) | SMN1; SMN2CSNK1A1CLK4ABL1BCR | |
| SCHEMBL21815333 | 0.77 | ABL1 (0.44) | SMN1; SMN2CSNK1A1CLK4ABL1BCR | |
| SCHEMBL4770277 | 0.76 | KDM4E (0.43) | SMN1; SMN2CSNK1A1CLK4MAPTRET | |
| SCHEMBL4772622 | 0.74 | KMT2A (0.51) | SMN1; SMN2MAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |