Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.45 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220525 | 0.85 | CCNA2 (0.60) | CCNA2CDK2CCNA1ALDH1A1LMNA | |
| SCHEMBL4766348 | 0.84 | CCNA2 (0.59) | CCNA2CDK2CCNA1ALDH1A1POLB | |
| SCHEMBL4772085 | 0.83 | CCNA2 (0.56) | CCNA2CDK2CCNA1ALDH1A1LMNA | |
| SCHEMBL4765289 | 0.83 | CCNA2 (0.57) | CCNA2CDK2CCNA1ALDH1A1LMNA | |
| SCHEMBL4770586 | 0.82 | CCNA2 (0.59) | CCNA2CDK2CCNA1ALDH1A1LMNA | |
| SCHEMBL4772639 | 0.82 | CCNA2 (0.57) | CCNA2CDK2CCNA1ALDH1A1LMNA | |
| SCHEMBL4773508 | 0.82 | CCNA2 (0.51) | CCNA2CDK2CCNA1ALDH1A1LMNA | |
| SCHEMBL4772200 | 0.82 | CCNA2 (0.54) | CCNA2CDK2CCNA1ALDH1A1LMNA | |
| SCHEMBL24478140 | 0.81 | CDK2 (0.47) | CCNA2CDK2CCNA1 | |
| SCHEMBL5723348 | 0.81 | CDK2 (0.61) | CCNA2CDK2CCNA1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |