Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.61 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.44 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723722 | 0.88 | CDK2 (0.48) | CDK2CCNA2CCNA1CDK1KDR | |
| SCHEMBL6220525 | 0.84 | CCNA2 (0.60) | CDK2CCNA2CCNA1POLBCXCR4 | |
| SCHEMBL4766348 | 0.84 | CCNA2 (0.59) | CDK2CCNA2CCNA1POLBCXCR4 | |
| SCHEMBL5723577 | 0.83 | SYK (0.49) | CDK2CCNA2CCNA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5723725 | 0.82 | CDK2 (0.50) | CDK2CCNA2CCNA1CDK1KDR | |
| SCHEMBL4765289 | 0.82 | CCNA2 (0.57) | CDK2CCNA2CCNA1POLBCXCR4 | |
| SCHEMBL4770586 | 0.81 | CCNA2 (0.59) | CDK2CCNA2CCNA1POLBCXCR4 | |
| SCHEMBL4772085 | 0.81 | CCNA2 (0.56) | CDK2CCNA2CCNA1POLBCXCR4 | |
| SCHEMBL4766601 | 0.81 | CCNA2 (0.58) | CDK2CCNA2CCNA1POLBCXCR4 | |
| SCHEMBL5723409 | 0.80 | CDK1 (0.56) | CDK2CCNA2CCNA1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406876-B1 | 2-ANILINO-PYRIMIDINE DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-12-27 | — | — | EP | disclosed |