Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1673945 | 0.86 | GPR119 (0.57) | GPR119MAPTALDH1A1LMNAHPGD | |
| SCHEMBL386411 | 0.85 | GPR119 (0.77) | GPR119MAPTALDH1A1HTTMEN1 | |
| SCHEMBL5259360 | 0.84 | GPR119 (0.60) | GPR119MAPTALDH1A1LMNAHPGD | |
| SCHEMBL5262571 | 0.83 | GPR119 (0.44) | GPR119MAPTALDH1A1LMNAHPGD | |
| SCHEMBL5262573 | 0.81 | GPR119 (0.53) | GPR119MAPTALDH1A1LMNAHPGD | |
| SCHEMBL6253407 | 0.74 | GPR119 (0.44) | GPR119MAPTALDH1A1LMNAHPGD | |
| SCHEMBL6041164 | 0.72 | GPR119 (0.59) | GPR119MAPTALDH1A1HTTTDP1 | |
| SCHEMBL1674095 | 0.72 | GPR119 (0.73) | GPR119MAPTALDH1A1LMNAHPGD | |
| SCHEMBL1674020 | 0.72 | GPR119 (0.76) | GPR119MAPTALDH1A1LMNAHPGD | |
| SCHEMBL27632009 | 0.71 | GPR119 (0.57) | GPR119MAPTALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1927594-A1 | 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia | Arena Pharmaceuticals, Inc. (US) | 2008-06-04 | — | — | EP | disclosed |