Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.71 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.69 |
| ▸ | CES2 | O00748 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11396292 | 0.88 | KAT6A (0.61) | KCNK3LMNAKAT6ATLR7NPSR1 | |
| SCHEMBL30069240 | 0.87 | LMNA (0.73) | KCNK3LMNAKAT6ATLR7CES2 | |
| SCHEMBL6841053 | 0.85 | KCNK3 (0.70) | KCNK3LMNAKAT6ATLR7P2RX1 | |
| SCHEMBL28971351 | 0.85 | TLR7 (0.63) | KCNK3LMNAKAT6ATLR7CES2 | |
| SCHEMBL28020270 | 0.84 | KCNK3 (0.65) | KCNK3LMNAKAT6AP2RX1ALDH1A1 | |
| SCHEMBL18311316 | 0.84 | KAT6A (1.00) | KAT6AGAA | |
| SCHEMBL30739929 | 0.83 | LMNA (1.00) | KCNK3LMNAP2RX1ALDH1A1GAA | |
| SCHEMBL4517587 | 0.83 | LMNA (1.00) | KCNK3LMNAP2RX1ALDH1A1GAA | |
| SCHEMBL6991713 | 0.83 | LMNA (0.67) | KCNK3LMNAKAT6ACES2NPSR1 | |
| SCHEMBL14527438 | 0.82 | TLR7 (0.64) | KCNK3LMNAKAT6ATLR7CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108779078-A | New inhibitor and probe of kinases and application thereof | 北京大学深圳研究生院 | 2018-11-09 | — | — | CN | disclosed |
| EP-1928844-A2 | BIS-ARYL AMIDE COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007022380-A2 | BIS-ARYL AMIDE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-02-22 | — | — | WO | disclosed |