Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | ERN1 | O75460 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720343 | 0.88 | CYP2C19 (0.69) | CYP2C9ALDH1A1CYP1A2CYP2D6ERN1 | |
| SCHEMBL4572856 | 0.86 | CYP2C9 (0.57) | CYP2C9ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL30969330 | 0.85 | ALDH1A1 (0.71) | CYP2C9ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL14048045 | 0.85 | CYP1A2 (0.59) | CYP2C9ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL29605727 | 0.84 | CYP1A2 (0.74) | CYP2C9ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL4268373 | 0.83 | MAPT (0.73) | CYP2C9ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL280088 | 0.83 | HSD17B10 (0.72) | CYP2C9ALDH1A1NPSR1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL2457432 | 0.83 | ALDH1A1 (0.56) | CYP2C9ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL19634715 | 0.83 | PARP1 (0.58) | CYP2C9ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL842621 | 0.82 | HSD17B10 (0.70) | CYP2C9NPSR1CYP1A2CYP2D6ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928844-A2 | BIS-ARYL AMIDE COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2008-06-11 | — | — | EP | claimed |
| WO-2007022380-A2 | BIS-ARYL AMIDE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-02-22 | — | — | WO | claimed |