Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.53 |
| ▸ | EDNRA | P25101 | 4/20 | 0.53 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.44 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5787263 | 0.95 | AGTR1 (0.56) | AGTR1EDNRAACHELTB4R2AGTR2 | |
| SCHEMBL5788663 | 0.92 | AGTR1 (0.59) | AGTR1EDNRAACHELTB4R2AGTR2 | |
| SCHEMBL4764964 | 0.92 | AGTR1 (0.59) | AGTR1EDNRAACHELTB4R2AGTR2 | |
| SCHEMBL4769446 | 0.91 | AGTR1 (0.56) | AGTR1EDNRAACHELTB4R2AGTR2 | |
| SCHEMBL4771286 | 0.90 | AGTR1 (0.55) | AGTR1EDNRAACHELTB4R2AGTR2 | |
| SCHEMBL4767110 | 0.90 | AGTR1 (0.53) | AGTR1EDNRAACHELTB4R2AGTR2 | |
| SCHEMBL5531642 | 0.90 | AGTR1 (0.56) | AGTR1EDNRAACHELTB4R2AGTR2 | |
| SCHEMBL4767459 | 0.89 | EDNRA (0.56) | AGTR1EDNRAACHELTB4R2AGTR2 | |
| SCHEMBL4775967 | 0.89 | AGTR1 (0.54) | AGTR1EDNRAACHELTB4R2AGTR2 | |
| SCHEMBL4769923 | 0.89 | AGTR1 (0.54) | AGTR1EDNRAACHELTB4R2AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002837-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-17 | — | — | EP | disclosed |