Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21349076 | 0.84 | SMN1; SMN2 (0.72) | HSD17B10LMNAL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL1018491 | 0.83 | KMT2A (0.54) | HSD17B10LMNASMN1; SMN2TP53CYP3A4 | |
| SCHEMBL18343123 | 0.82 | HSD17B10 (0.78) | HSD17B10LMNAL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL21348646 | 0.82 | FFAR1 (0.55) | HSD17B10LMNAL3MBTL1SMN1; SMN2RECQL | |
| SCHEMBL8251623 | 0.82 | SMN1; SMN2 (0.62) | HSD17B10LMNAL3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL21217871 | 0.81 | HSD17B10 (0.56) | HSD17B10LMNAL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL10272937 | 0.81 | SMN1; SMN2 (0.58) | HSD17B10LMNAL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL10765557 | 0.81 | SMN1; SMN2 (0.63) | HSD17B10LMNAL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL10224883 | 0.81 | HSD17B10 (0.50) | HSD17B10LMNAL3MBTL1SMN1; SMN2RECQL | |
| SCHEMBL14885455 | 0.81 | RAB9A (0.62) | SMN1; SMN2TP53CYP3A4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948659-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |