Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2104968 | 1.00 | CENPE (0.58) | CENPEMEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL2105954 | 0.94 | CENPE (0.61) | CENPEMEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL2104926 | 0.92 | CENPE (0.56) | CENPEMEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL2101183 | 0.91 | CENPE (0.59) | CENPEMEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL2104243 | 0.90 | CENPE (0.56) | CENPEMEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL2106289 | 0.89 | CENPE (0.53) | CENPEMEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL13163041 | 0.89 | CENPE (0.54) | CENPEMEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL2105004 | 0.87 | CENPE (0.54) | CENPEMEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL4774113 | 0.87 | CENPE (0.54) | CENPEMEN1KMT2ATAS1R3TAS1R1 | |
| SCHEMBL3469159 | 0.86 | CENPE (0.51) | CENPEMEN1KMT2ATAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742907-A4 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1742907-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005107762-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-11-17 | — | — | WO | disclosed |