Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL14691766 | 0.94 | MAOA (0.44) | MAOAMAOBOPRL1OPRM1OPRK1 | |
| SCHEMBL8893055 | 0.92 | MAOA (0.45) | MAOAMAOBOPRL1OPRM1OPRK1 | |
| Ammonia Solution, Strong SCHEMBL14691839 | 0.84 | MAOA (0.48) | MAOAMAOBOPRL1OPRM1OPRK1 | |
| SCHEMBL4616975 | 0.78 | MAOB (0.37) | MAOAMAOBOPRM1ALDH1A1HTT | |
| SCHEMBL3906018 | 0.77 | MAOA (0.39) | MAOAMAOBOPRL1OPRM1OPRK1 | |
| SCHEMBL60702 | 0.76 | MAOA (0.41) | MAOAMAOBOPRL1OPRM1OPRK1 | |
| SCHEMBL14778815 | 0.76 | MAOA (0.43) | MAOAMAOBHTTKDM1AKMT2A | |
| SCHEMBL27668036 | 0.75 | MAOA (0.40) | MAOAMAOBOPRL1OPRM1OPRK1 | |
| SCHEMBL706405 | 0.74 | MAOA (0.35) | MAOAMAOBALDH1A1HTTKDM1A | |
| SCHEMBL10440587 | 0.74 | MAOA (0.39) | MAOAMAOBOPRL1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940835-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007036733-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |