Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791853 | 0.99 | MAPK14 (0.98) | MAPK14 | |
| SCHEMBL4762691 | 0.96 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL4828255 | 0.92 | MAPK14 (0.96) | MAPK14 | |
| SCHEMBL4764118 | 0.91 | MAPK14 (0.98) | MAPK14 | |
| SCHEMBL6069066 | 0.90 | MAPK14 (0.79) | MAPK14 | |
| SCHEMBL4762629 | 0.90 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL4762668 | 0.90 | MAPK14 (0.96) | MAPK14 | |
| SCHEMBL4771246 | 0.89 | MAPK14 (0.98) | MAPK14 | |
| SCHEMBL6068731 | 0.88 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL6068993 | 0.88 | MAPK14 (0.75) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537108-B1 | DI AND TRIFLUORO-TRIAZOLO-PYRIDINES ANTI-INFLAMMATORY COMPOUNDS | PFIZER PROD INC (US) | 2008-11-19 | — | — | EP | disclosed |
| US-7259171-B2 | Di and trifluoro-triazolo-pyridines anti-inflammatory compounds | PFIZER INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7012143-B2 | Cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines | DOMBROSKI MARK A | 2006-03-14 | — | — | US | disclosed |
| EP-1537108-A1 | DI AND TRIFLUORO-TRIAZOLO-PYRIDINES ANTI-INFLAMMATORY COMPOUNDS | Pfizer Products Inc. (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040087615-A1 | Cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines | PFIZER INC | 2004-05-06 | — | — | US | disclosed |
| US-20040053958-A1 | Di and trifluoro-triazolo-pyridines anti-inflammatory compounds | PFIZER INC. | 2004-03-18 | — | — | US | disclosed |
| WO-2004020440-A1 | DI AND TRIFLUORO-TRIAZOLO-PYRIDINES ANTI-INFLAMMATORY COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2004-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053958-A1 | Di and trifluoro-triazolo-pyridines anti-inflammatory compounds | MAPK1, CNKSR1, CCR2 | MAPK14 128/4885 |
| US-20040087615-A1 | Cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines | MAP4K2, MAPK1, MAP3K1 | MAPK14 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.