Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5441881 | 1.00 | EPHX1 (0.56) | EPHX1POLBSMN1; SMN2LMNANPSR1 | |
| SCHEMBL4794135 | 0.92 | EPHX1 (0.46) | EPHX1SMN1; SMN2LMNANPSR1HSD11B1 | |
| SCHEMBL14540867 | 0.92 | EPHX1 (0.46) | EPHX1SMN1; SMN2LMNANPSR1HSD11B1 | |
| SCHEMBL4793633 | 0.91 | EPHX1 (0.45) | EPHX1SMN1; SMN2LMNANPSR1HSD11B1 | |
| SCHEMBL5437855 | 0.90 | EPHX1 (0.52) | EPHX1SMN1; SMN2LMNANPSR1HSD11B1 | |
| SCHEMBL4767981 | 0.90 | EPHX1 (0.43) | EPHX1SMN1; SMN2LMNANPSR1HSD11B1 | |
| SCHEMBL4768030 | 0.89 | EPHX1 (0.43) | EPHX1POLBSMN1; SMN2LMNANPSR1 | |
| SCHEMBL4770967 | 0.89 | EPHX1 (0.47) | EPHX1SMN1; SMN2LMNANPSR1HSD11B1 | |
| SCHEMBL4777331 | 0.89 | HSD11B1 (0.44) | EPHX1SMN1; SMN2LMNANPSR1EPHX2 | |
| SCHEMBL14540677 | 0.89 | HSD11B1 (0.44) | EPHX1SMN1; SMN2LMNANPSR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931652-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2008-06-18 | — | — | EP | claimed |
| WO-2007038138-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-04-05 | — | — | WO | claimed |
| EP-1931652-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007038138-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |