Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.31 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.30 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769817 | 0.86 | PARP1 (0.44) | PARP1PARP2PARP3TIPARP | |
| SCHEMBL4763039 | 0.79 | PARP1 (0.39) | PARP1TIPARP | |
| SCHEMBL2266028 | 0.77 | PARP1 (0.43) | PARP1PARP14TIPARP | |
| SCHEMBL2264959 | 0.77 | PARP1 (0.44) | PARP1PARP14PARP2PARP3 | |
| SCHEMBL2267062 | 0.75 | PARP1 (0.38) | PARP1PARP2 | |
| SCHEMBL2263875 | 0.74 | PARP1 (0.42) | PARP1PARP14PARP2PARP3 | |
| SCHEMBL2265233 | 0.73 | PARP1 (0.43) | PARP1PARP14PARP2PARP3 | |
| Ammonia Solution, Strong SCHEMBL28920665 | 0.72 | PARP1 (0.44) | PARP1TIPARP | |
| SCHEMBL4766393 | 0.71 | PARP1 (0.37) | PARP1PARP2 | |
| Trifluoroacetic Acid SCHEMBL2265228 | 0.71 | PARP1 (0.44) | PARP1PARP14PARP2PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007733-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007113596-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-10-11 | — | — | WO | disclosed |