Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 15/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 13/20 | 0.43 |
| ▸ | PARP3 | Q9Y6F1 | 12/20 | 0.43 |
| ▸ | TIPARP | Q7Z3E1 | 5/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768369 | 0.86 | PARP1 (0.40) | PARP1PARP2PARP3TIPARP | |
| SCHEMBL4770118 | 0.79 | PARP1 (0.45) | PARP1PARP2PARP3TIPARPTNKS | |
| SCHEMBL2267536 | 0.76 | PARP1 (0.39) | PARP1PARP2PARP3TIPARPTNKS | |
| SCHEMBL27738232 | 0.70 | PARP1 (0.53) | PARP1PARP2PARP3TIPARP | |
| SCHEMBL2268484 | 0.69 | PARP1 (0.40) | PARP1PARP2PARP3TIPARPTNKS | |
| SCHEMBL4764905 | 0.69 | PARP1 (0.61) | PARP1PARP2PARP3 | |
| SCHEMBL4769834 | 0.69 | PARP1 (0.40) | PARP1PARP2PARP3TNKSPARP10 | |
| SCHEMBL2266054 | 0.69 | PARP1 (0.38) | PARP1PARP2PARP3TNKSPARP10 | |
| SCHEMBL2269991 | 0.69 | PARP1 (0.54) | PARP1PARP2PARP3 | |
| SCHEMBL2269108 | 0.69 | PARP1 (0.63) | PARP1PARP2PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007733-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007113596-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-10-11 | — | — | WO | disclosed |